I have done it to cocktail an activator for the temp I was spraying in. Nowadays, there are usually a high temp, medium and low temp (or slow, medium, and fast) activators made for every type of clear, but back when I was doing it, there were often only two,...an overall paint job clear, (slow) and a panel paint clear (fast).
I would never try it with different brand hardeners, or do it using hardeners not made for the brand paint I am using.