- Anthony S. Fauci, M.D.,
- H. Clifford Lane, M.D.,
- and Robert R. Redfield, M.D.
- March 26, 2020
N Engl J Med 2020; 382:1268-1269
If one assumes that the number of asymptomatic or minimally symptomatic cases is several times as high as the number of reported cases, the case fatality rate may be considerably less than 1%. This suggests that the overall clinical consequences of Covid-19 may ultimately be more akin to those of a severe seasonal influenza (which has a case fatality rate of approximately 0.1%) or a pandemic influenza (similar to those in 1957 and 1968)