The biggest problem i can think of for street use is the volume of fuel needed, which is 2.2 times that of gasoline. That is a lot of fuel!
another problem is trying to keep the motor lean under cruise conditions and idle, to help with the oil problem and give some semblance of milage, so you don't run out five miles from home!!.
Third, keeping engine temp up around 190 degrees will definately help with the oil, and i don't have to change mine very often because the heat boils the alky away.
Water is the main byproduct of methanol, and there will be some getting by into the oil, and getting the temp up around 220 for a while will cure that. I have had oil that looked like chocolate milk, and after heating the motor to 220 degrees, it boiled all of the water and alky away. Alky boils at 149, water 212, so the higher temp is needed to get rid of both.
I have run the same oil in my drag car on alky longer than i would have on gas, because gas can mix with oil and ruin it, alky can't and will boil away if gotten warm enough.
Methanol needs LESS timing than gasoline, about 2 degrees less.
It is improtant to clear the engine of any fuel residue when you shut it off for the day, to keep corrosion down. I run a top lube,(klotz brand) and with an injecter I can just shut the fuel off and let it starve, don't know what to do about a carb setup, other than maybe having a large enough leanout (1/2 inch?) so you could open it up and crank the motor with the ignition on to clear out the cylinders without pulling more fuel.