Lot's of issues with one being cylinders are too short to adequately guide the piston at TDC and you would have to have a custom crank made as well as 6.000 rods wouldn't clear. 99% of LS cranks which are cam-cut for 6.125 long rods. Rods may or may not hit cam at 4.250 stroke depending on many factors. pistons might hit main webbing at BDC too depending on piston shape and skirt profiling and design. Crank might not balance without a lot more heavy metal as well.
Pistons hitting anything should not be an issue as they aren't coming out of the bottom of the sleeve any more than a 4.000"/6.125" combo.
What do you mean about the cylinders being too short to guide the piston at tdc?
Obviously the crank and rods would not necessarily be shelf items. But what do you mean by needing a custom crank as the 6.000" rods wouldn't clear? Wouldn't clear what?
Rod ratio is doesn't seem that far out of control at 1.41.
Looking for input for a motor that would be mainly drag raced with the occasional cruise night. Probably less than 4000 miles a year. Not scared to freshen up once a year. It would more than likely also be encouraged by miller lite and a procharger.
Just looking for something a little different than your run of the mill cookie cutter combos.