Going EFI by it self will not take away the hot holes!!!
What it will do is give you more controll over your fuel and timing to help with the hot holes and being able to help tune it out a little ezer.
It allows you to do things with the fuel curves that you just can't do with a carb/carbs. With this extra controll it will help make the engine happier.
With EFI you also have the abillity to let the efi unit make some changes down track with O2 corrections (some use 10%, I like no more than 5% if your using this opion) on the fuel side.
On the ind. cylinders you can add/remove timing and fuel for each (hot) hole of the engine.
Also what efi will do to help all cylinders burn the same is that fuel is added to each runner for the engine use all the time by the injectors unlike the fuel being pulled/sucked into the runners from the carb/carbs. Because of this the amount of fuel you will add for each stage of nitrous will be so much less than what you do on a wet kit (fuel in the runner already there for engine use and not having to add fuel to the system to make up for the lose of signal/fuel from the carb/carbs).
Assuming the injectors are closely matched, you still have air distribution of the intake and throttle bodies which is still a very real condition, hence the need for a best case designed intake and throttle body.
I agree with the others here. There are many things that can effect the cylinder to cylinder needs of any engine. Air flow, fuel flow, cooling, valve lash and cam timing, port design and so on just to name a few.. Regardless of the type of induction, you'll alway have to watch ALL plugs to tune properly.. SJ