The small turbo will see whatever back pressure it normall would at the PR and corrected airflow (actual airflow divided by big turbo PR) you run it at, as long as there is enough WG capacity. But, the large turbo backpressure will be multiplied by the small turbo's turbine PR. The compounding works in both directions. IMO, the hotside on the small turbo is of little consequence (as long as it "makes sense" and there is enough WG), it's the large turbo backpressure that hurts more since it gets multiplied. They both batter of course since the small turbo is the multiplier, but either way, the small turbo doesn't give you much choice, you need whatever turbine setup it needs to spool. The big turbo gives you many more options, and in my opinion, you really can't go too big here. To use an extreme, impossible example to illustrate the point, imaging a big turbo with a turbine side so big that it gave no back pressure. You would effectively double your flow for the same BP you'd get from the small turbo on it's own.
In my case the T3 .82 housing on the stage 3 turbine T04E 50 trim is a reasonable turbo for a 2 liter. Back pressure would certainly be acceptable on its own. The trick is the big turbo though, I only see 9-10 psi backpressure from it. This is what keeps the total back pressure from getting over 1:1. The same big turbo with nitrous to spool would be far less than 1:1 of course, but that defeats the purpose.
In short, if you are able to run the large turbo on the motor alone, without compounding it, it's probably way too small on the turbine side for compounding.